It's MTV's second annual Musical March Madness! MTV News took the 64 biggest names in rock, split them up into four regions, assigned them seeds and puts them up against one another in a single-elimination series of match-ups in a winner-take-all contest. We're leaving it to you to decide an actual champ in this field of 64, so over the next few weeks, fan voting will determine who will emerge as this year's champion. It's all about the fans, and the artist with the most passionate fan base will score the awesome Musical March Madness trophy!

Welcome back to the East region, where upsets abound and contenders are born. The second round has been intense, and it promises to stay that way as we move into the weekend. The biggest Cinderella in the whole tournament is up, with the Sweet 16 hanging in the balance.

Voting for all second round match-ups will close on Sunday, March 27 at midnight. As always, you can follow all the voting here.

(8) Coldplay vs. (16) Sum 41

The biggest upset of the first round came when Sum 41 (who are about to drop a new album called Screaming Bloody Murder) upended fellow Canadian countrymen Arcade Fire (who rode their big Grammy victory for Album of the Year to a number one seed). For their trouble, they'll have to go up against worldwide superstars Coldplay, who dropped Cake in round one without much fuss. Who will stand tall once the voting ends? Only you know the answer!

Watch the breakdown of the first round and a preview of round two!

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Check out the Musical March Madness bracket and be take a look at the hoops-centric photos of some of the tournament's biggest bands.