It's MTV's second annual Musical March Madness! MTV News took the 64 biggest names in rock, split them up into four regions, assigned them seeds and puts them up against one another in a single-elimination series of match-ups in a winner-take-all contest. We're leaving it to you to decide an actual champ in this field of 64, so over the next few weeks, fan voting will determine who will emerge as this year's champion. It's all about the fans, and the artist with the most passionate fan base will score the awesome Musical March Madness trophy!

The second round is almost completely open, though there is plenty of action still to come today (and over the weekend). Some of the Sweet 16 teams are coming into focus, while others remain up in the air. This particular pairing is especially intriguing, as it pits a perennial favorite against a surprise underdog.

Voting for all second round match-ups will close on Sunday, March 27 at midnight. As always, you can follow all the voting here.

(3) My Chemical Romance vs. (11) Rage Against the Machine

Despite not having released new music in years, Rage Against the Machine took down current modern rock chart kings Cage the Elephant in a first round drubbing. They'll square off against My Chemical Romance, who stomped all over Panda Bear in the opening round in hopes of securing the championship trophy this year (they fell in the finals of 2010's tournament). Will they continue their surge, or will Rage continue their unlikely run? Vote to find out!

Watch the breakdown of the first round and a preview of round two!

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Check out the Musical March Madness bracket and be take a look at the hoops-centric photos of some of the tournament's biggest bands.