"At some point, I hope [to make a "Family Guy" movie]," he insisted. "The trick is to find a way to do it and do the series at the same time. That's almost impossible and I think that's why it took 'The Simpsons' twenty years. Hopefully it's sooner rather than later."

But should Peter, Lois, Stewie and the rest of the Griffin family meet resistance on their way to the multiplex, no worries, joked MacFarlane...he's already got a live-action cast picked out to appease the bean counters.

"I guess Juliette Lewis would be Meg, David Hyde Pierce would be Stewie," he chuckled. "Ann Coulter would be Brian. Let's see, Rosie O'Donnell would be Peter - she'd do a good job, she's talented, a multi-faceted entertainer."

"Who did I leave out?" MacFarlane laughed. "Oh, Chris! Phillip Seymour Hoffman! And of course Lois would be, let's give it to Kathy Griffin for god's sakes. She's paid her dues!"

Take notice Fox execs, live-action or animated, MacFarlane already has a plot as well. "Something to do with Pauley Shore, that's all I know," he said.

For real, would you be anxious for a "Family Guy" flick? What's your favorite joke from the series? Sound off below.