Seth MacFarlane and Charlize Theron Agree: It Takes a Pair (in The West)

...Of people, that is.

With reporting by Chris Kim

Listen: no one thinks it's really all that hard for Seth MacFarlane to be funny. He's the creator of "Family Guy" and "Ted," verdamnit: so taking risks is not something he's really all that disinclined to do.

But still! When it comes to taking an iconic genre like the Western and turning it into his personal brand of silly tomfoolery? Well, now that sorta takes some balls. Luckily, between himself and his "A Million Ways to Die in the West" costar Charlize Theron, they "certainly do" have a full pair — which is just enough to do something this kinda-crazy (in a good way) and get away with it — at least, as MTV News found out when we sat down with the duo.

"A Million Ways to Die in the West" opens May 30. Balls not included.