Gaga is up for Best Female, Best Live Act, Best Pop Act, Best Song and Best Video for "Born This Way." She scored the sixth nom in the Biggest Fans category, an honor she'll share with her Little Monsters if she wins.
American and Canadian audiences can vote for the North American nominee for the Worldwide Act award, who will represent the continent at the EMAs against contenders from across the globe.
So, who will go head-to-head with the superstar? Adele's unstoppable "Rolling in the Deep," Bruno Mars' "Grenade," Jennifer Lopez's "On the Floor" (featuring Pitbull) and Katy Perry's "Firework" will go up against Gaga for Best Song.
For Best Pop, Britney Spears, Bieber, Perry, Rihanna and Gaga are set to face off, while Adele, Beyoncé, J.Lo, Katy and Gaga also made the final cut for Best Female.
Battling it out in the Best Male category are Bruno Mars, David Guetta, Bieber, Kanye West and Eminem, who's also up for Best Hip Hop alongside Lil Wayne, Jay-Z and Kanye West (a.k.a. the Throne), Pitbull and Snoop Dogg.
Coldplay, the Foo Fighters, Linkin Park, Kings of Leon and Red Hot Chili Peppers are up for Best Rock. And the night's big prize, Best Video, features the most eclectic mix of nominees: Adele's "Rolling in the Deep," the Beastie Boys' "Make Some Noise," Beyoncé's "Run the World (Girls)," Justice's "Civilization" and Gaga's "Born This Way."
On Monday morning (September 19), Bieber reacted to the nods on Twitter, writing, "Just got word that we got 3 MTV EMA Nominations for Best Male, Best Pop, Biggest Fans!! THANKS SO MUCH! LEt's VOTE!!!"
Well, those fans better take note. Beliebers voting in the Biggest Fans category will face off against his girlfriend Selena Gomez's followers, Thirty Second to Mars' devotees, Paramore's biggest admirers and, of course, Lady Gaga's Monsters.
The MTV Europe Music Awards air live on November 6 from Belfast, Ireland. For a complete list of nominees and to vote for your favorite artists, check out the MTV EMA website. Stick with MTV News as we roll out more information on performers and presenters.