[artist id="860639"]50 Cent[/artist] obviously isn't waiting for [artist id="510062"]Lil Wayne[/artist] to explain. But the [artist id="1237480"]G-Unit's[/artist] commander-in-chief is keeping an ear out for a response from the New Orleans native. 50 disses Wayne, Oprah Winfrey and apparently [artist id="1230523"]Kanye West[/artist] in a new record called "Play This on the Radio."

"First they said that f----t's hot, then they let that junkie shine," [article id="1601504"]50 raps to lead off the record[/article]. "Gave him all the f---in' trophies, tell me, where the f--- is mine?"

As the song closes out, 50 threatens Wayne.

"I'm on your heels, Mr. Carter. I heard you. You want me to 'die ugly?' OK. Don't end up on the list, n---a. Be a missing person like [artist id="400206"]Cam'ron[/artist], like [artist id="508987"]Ja [Rule][/artist], like [artist id="611"][Fat] Joe[/artist]. Who wants some?"

50 called into DJ Whoo Kid's satellite radio show on Saturday and alluded that the first part of his rap was aimed at Kanye West, and confirmed that the second part was aimed at Lil Wayne. Fif explained his latest barbs at Weezy were in response to a record called "Louisianimal" that landed on mixtapes in November. (The song debuted on a mixtape by the Empire, whom Wayne has repeatedly admonished in public for bootlegging his dated material.)

On the record, Lil Wayne threw a light but obvious jab at 50, saying, "All about a dollar, f--- two quarters/ B---h, I'll pour syrup in that vitamin water/ I hope you die ugly, and tonight will be gorgeous."

"When he said it, I don't know if it was old or new material," 50 explained to Whoo Kid. "But because he didn't say anything [to clarify the timing of the song], I take it that he meant for it to be out there right now. When that hit the street and you don't hear him say, 'That was old' ... Em don't got time for you, period. I will mop the streets with your a--."

50 started shooting disses at Wayne a while back, in the wake of Weezy being named [url id="http://www.mtv.com/bands/h/hip_hop_week/2007/hottest/index12.jhtml"]MTV News' Hottest MC in the Game in 2007[/url]. 50 also said he had provocation to dis Wayne before because Weezy was working with a slew of his rivals -- including Ja Rule, Fat Joe and [artist id="1833864"]the Game[/artist] -- but didn't actually have real hatred toward Wayne. Tensions between the two seemed to substantially subside over the past year and change. There were even negotiations between Wayne and the G-Unit to tour together. However, the pleasantries seemed to go out the window once "Louisianimal" appeared.

50 told Whoo Kid that a response to "Play This on the Radio" would be a foolhardy effort on Weezy's behalf.

"If he says something back, I'm gonna drop the bomb on his a--," 50 warned. "It's gonna be hard for me to get off him.

"He's a talented artist," Fif continued, "but if you put him in a space when we're in direct competition, my consistency will break his neck."

Also during the interview, 50 talked about the shot he takes at Oprah Winfrey in "Play This on the Radio" ("I don't wanna chit-chat on your sofa/ I ain't Jay-Z, f--- you Oprah"), accusing Winfrey yet again of being "prejudiced" against hip-hop.

50 Cent's next LP, [article id="1599371"]Before I Self Destruct, [/article] is slated for an early February release.