Ophidian may refer to:
Ophidian, a reptile of the suborder Ophidia (or Serpentes); a snake,
Ophidian (wrestler), a professional wrestler,
Ophidian (Dungeons & Dragons), a Dungeons & Dragons monster,
Ophidian 2350, a collectible card game,
Ophidian of the Emotional_spectrum, a being that is the universal embodiment of the emotion of avarice,
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