Catherine Blake was the wife of William Blake.
Catherine Blake or similar may also refer to:
Catherine C. Blake (born 1950), American judge,
Katharine Blake (singer) (born 1970), British musician,
Dorothy J. Heydt, American author, pen name Katherine Blake,
Katherine Blake (character), killer on the soap opera Shortland Street,
Katharine Blake (actress) (1921-1991), South African actress