- SIXsidedDIE -- Sjef Van Leeuwen
- SJH -- Skandinieki
- Skandle Oso -- Skeeter Billz
- Skeeter Bonn -- Skidmark
- Skidmore -- Skintrade
- Skintrade -- Skitz & Rodney P.
- Skitzo -- Skrill Will
- Skrilla -- Sky Blue
- Sky Blue -- Skyla Vertex
- Skylab -- Slackjaw
- Slackk -- Slaskfittorna
- Slate -- Sleep Fairy
- Sleep for Sleepers -- Sleepyeyez
- Sleepyhead -- Slideride
- Slider's Fault -- Slim Tingley & Band
- Slim Tinsley And His Band -- Slo V & Retro
- Sloan -- Slow Jams
- Slow Jets -- Slumberlandband
- Slumberstar -- Smackdown
- Smackfactor -- Smartbomb CA
- Smarter Than Your Average -- Smiles & l'Hat Productions
- Smiles Project -- Smithtown Gospel Tabernacle Worship Choir
- Smithtown Riot -- Smokey Dee
- Smokey Ellison -- Smooth Stab
- Smooth Styler Jb -- Snagged
- Snagger -- Snawklor