Amber was just a typical Midwestern teen when she got pregnant with her first child Leah at 16 with her first real boyfriend Gary. Years later, Amber has another child James with her ex Andrew, with whom she's currently in an extended custody battle. Open about her experiences with mental illness, Amber works to stay healthy for herself and her kids. Now, Amber's relationship with her daughter Leah has hit an all-time low, with Leah cutting off all communication. Amber attempts to rebuild burnt bridges with Leah and Gary while striving to achieve a psychology degree.

Small-town sweethearts Catelynn and Tyler chose adoption for their first daughter Carly, and the heartbreaking decision changed their lives forever. Years later, Catelynn and Tyler are still married and work to provide a happy home for their family. Making the decision to have their fourth (and final) child, Catelynn and Tyler set their hopes on a boy. After discovering they will have yet another daughter, they prepare for a house full of girls and contemplate having their oldest daughter Nova in the delivery room. Catelynn continues to work toward a microblading career, and Tyler's insecurities prompt him to try ketamine therapy.

After a fling, Cheyenne found herself co-parenting with Cory, her castmate on The Challenge. Their daughter Ryder has VLCAD, a rare genetic disorder, so Cheyenne works hard to bring awareness to and raise funds for the condition. While things did not work out between Cheyenne and Cory, they maintain a healthy co-parenting relationship. Cheyenne rekindles a romance with her ex-boyfriend Zach, and their relationship escalates after she becomes pregnant. Now, as they await the birth of their son Ace, COVID-19 protocols make it difficult for Zach to be as involved with the pregnancy as he'd like. Deciding that he and Cheyenne need to make their relationship official, Zach surprises her with a proposal.

The all-American girl next door, Maci surprised everyone when she got pregnant in high school while dating her bad-boy boyfriend Ryan. Years later, Maci and Ryan still struggle to have a solid co-parenting relationship for their son Bentley. Now, raising three kids with her husband Taylor, Maci seemed to have a firm grasp on balancing life -- until now. Maci is suffering from PTSD due to her involvement in a gas station shootout, and the fallout is causing strain on her marriage and on her relationship with Bentley.

Mackenzie McKee, originally from Teen Mom 3, keeps busy juggling three kids and a business with her high school sweetheart Josh. After struggling with a long-distance relationship during a rough patch in their marriage, Mackenzie and Josh's relationship now gets stronger by the day with Josh permanently living in Florida. Mackenzie's fitness business is booming, but her busy life may be having a negative impact on her kids, who struggle with behavioral and education issues at school.