It's MTV's second annual Musical March Madness! MTV News took the 64 biggest names in rock, split them up into four regions, assigned them seeds and puts them up against one another in a single-elimination series of match-ups in a winner-take-all contest. We're leaving it to you to decide an actual champ in this field of 64, so over the next few weeks, fan voting will determine who will emerge as this year's champion. It's all about the fans, and the artist with the most passionate fan base will score the awesome Musical March Madness trophy!

Things are really starting to get serious in MTV's Musical March Madness, as the dominance of the Midwest region hangs in the balance. With Disturbed already throwing bombs against Patrick Stump, it's time to take a look at another key match-up that could very well decide who walks away the 2011 champion.

Voting for all Sweet 16 match-ups will close on Tuesday, March 29 at midnight. As always, you can follow all the voting here.

(6) Coheed and Cambria vs. (7) Avenged Sevenfold

The defending champions have had a pretty easy trip to the Sweet 16 this year, as they have bested the likes of Crystal Bowersox and Vampire Weekend with ease. But now comes their first true test, as they'll have to knock out a very strong Avenged Sevenfold squad. The A7X boys surged through tough tests Taylor Swift and the Black Keys, so they're battle-tested and ready for a brawl. Will they be the ones to dole out Coheed's first Musical March Madness defeat? You decide!

Check out Dick Bagwell and Vincent Twice previewing the Sweet 16!

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Check out the Musical March Madness bracket and be take a look at the hoops-centric photos of some of the tournament's biggest bands.