It's MTV's second annual Musical March Madness! MTV News took the 64 biggest names in rock, split them up into four regions, assigned them seeds and puts them up against one another in a single-elimination series of match-ups in a winner-take-all contest. We're leaving it to you to decide an actual champ in this field of 64, so over the next few weeks, fan voting will determine who will emerge as this year's champion. It's all about the fans, and the artist with the most passionate fan base will score the awesome Musical March Madness trophy!

The South bracket has already delivered some surprises, and the match-up below represents the last of the region's second round voting. Tune in tomorrow for the East bracket's pairings, and remember that you should keep track of your favorite artists' progress, as anything can happen between now and when voting closes.

Voting for all second round match-ups will close on Sunday, March 27 at midnight. As always, you can follow all the voting here.

(2) Muse vs. (7) Weezer

Muse are sort of the quiet juggernaut of this tournament, as they had an excellent showing last year and topped Cobra Starship in the first round. They'll face off against Weezer, who walked all over My Morning Jacket in the round of 64. Which one of these rock titans will advance to the Sweet 16 to take on the winner of the Adele/Tokio Hotel winner? Only your votes know for sure!

Watch the breakdown of the first round and a preview of round two!

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Check out the Musical March Madness bracket and be take a look at the hoops-centric photos of some of the tournament's biggest bands.