The two actors will play brothers who don't have a lot in common. Segel is the titular Jeff, who lives at home, while Helms will be the more "together" sibling. Greer would play the latter's wife. Earlier this year, I predicted "Cyrus" star and admitted Duplass fan Jonah Hill would end up being one of the leads, but maybe there's another role for him somewhere. Apparently the part of the guys' mom still needs to be cast (hint, hint).

Helms, who really broke out with "The Hangover" last year, is being hired left and right these days. Hopefully that won't result in him leaving TV's "The Office" anytime soon. And hopefully he's not being too typecast here as another straight-laced guy who learns how to go wild -- or go mellow, since this is a pot movie.

If I hear anything about a stripper character or Greer's part being anything like the Rachael Harris role in "The Hangover," I'm going to be very suspicious. Knowing the work of the Duplass brothers, though, I strongly believe that this will be a lot more original than it sounds (and it sounds a little like "Step Brothers" at the moment).

"Jeff" is being produced by "Up in the Air" director Jason Reitman and John Malkovich (who hopefully makes at least a cameo) and is set to begin shooting in New Orleans next month.

Are Jason Segel and Ed Helms perfect for this stoner comedy? Or are you worried that both are being typecast?