We hope Jack Nicholson holds on to his seat, because on Thursday, September 6, the MTV 2012 Video Music Awards will be invading Staples Center in Los Angeles for the first time ever. Fans can expect to see music's brightest stars like Taylor Swift, Rihanna, Pink, Alicia Keys and Green Day take the VMA stage.

Even Game ditched his unmistakable gangsta scowl and lit up when he heard the news. "L.A. is beautiful, man," he told MTV News while on the set for his "Celebration" music video. "I think everything should be at the Staples Center, in life. I think birthday parties, quinceañeras, VMA Awards, everything should be at the Staples Center."

While MTV is gearing up to have the greatest moments ever in Staples Center history, the 20,000-seat arena already has housed some pretty unforgettable pop-culture moments. Here are some of the biggest.

Bruce Springsteen Opens The Staples: October 17, 1999
Though the Staples is most known as the home of the 17-time NBA champions, the L.A. Lakers, it was a New Jersey boy who christened the arena. On October 17, 1999 the $375 million construct opened its doors to Bruce Springsteen and the E Street Band who kicked off the opening day's festivities.

Home of the Grammy Awards
Since 2000, the Staples has hosted the Grammy Awards every year, except 2003 when the annual ceremony was held in New York's Madison Square Garden. Through the years, the likes of U2, Eminem, Alicia Keys and Jay-Z have all accepted golden gramophones in the famed arena, but who will take home the coveted Video of the Year Moonman this year? You have to tune in to find out.

2000 Democratic National Convention
In August 2000, Al Gore accepted the democratic presidential nomination at the DNC, but would eventually lose the election to George W. Bush later that year. Don't forget to vote.

Kobe Bryant Drops 81 Points In A NBA Game: January 22, 2006
Kobe Bryant has helped bring the city of L.A. five championships; it's kind of what he does. And while the basketball great has made a career of doing the unthinkable, in January 2006, Kobe dropped a whopping 81 points when the Lakers hosted the Toronto Raptors in the Staples Center. Now Bryant sits at #2 on the league's single-game scoring list, right behind Wilt Chamberlain's 100 point game way back in 1962.

Beyoncé Shares Her Live Experience
On September 2, 2007, Beyoncé thrilled Staples Center fans performing hits like "Crazy in Love," "Irreplaceable" and parading out all-star guests like Jay-Z and her Destiny Child homeys. Luckily for those of us he couldn't make it, Queen B edited and released the concert footage packaging it as her "Beyoncé Experience Live" DVD.

Rest In Peace To the Leader Of The Jackson 5
The Staples Center is literally fit for a king. After Michael Jackson's death, the Jackson Family held the memorial services for the King of Pop on July 7, 2009 and distributed tickets to fans for free.

Justin And Selena's Big Date
The Biebs sure knows how to treat a lady. Last September, Justin Bieber took his boo Selena Gomez to see Demi Lovato play at the Nokia Theatre in downtown Los Angeles. After the show, JB surprised Selena with a dinner date for two and a screening of "Titanic" in an empty Staples Center. "Romance isn't dead. Treat your lady right fellas," Justin tweeted after the date.

Jay-Z And Kanye Ball So Hard
Jay-Z and Kanye West could've easily called their critically acclaimed Watch the Throne Tour the Paris Tour. During each stop, the dynamic rap duo performed their ubiquitous hit numerous times, and when it came time to shoot the song's video, the Throne chose the Staples Center as the backdrop. Good choice, considering the clip is up for Best Hip Hop Video at this year's VMAs.

The 2012 MTV Video Music Awards were a blast! Stick with MTV for all the VMA winners, fashion, and continued coverage of everything that happened onstage, backstage and behind-the-scenes.

What's your favorite Staples Center moment? Or should we wait until after the VMAs to ask? Let us know in the comments!