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Other big names on hand to present include Kylie Minogue, Jada Pinkett Smith, Joe Jonas, Keri Hilson, Marc Anthony, "Glee" star Matthew Morrison, Nas, Scott Weiland, Tim Allen, Travis Barker, Trey Songz and "Modern Family" star Rico Rodriguez.
Rihanna, Jennifer Lopez, the Black Eyed Peas, Taio Cruz, Keith Urban and Lady Antebellum have all been tapped to perform at the show, which will air live on ABC from the Las Vegas MGM Grand.
Big nominees for the night include Rihanna (with a whopping 18 nods), Eminem, Lady Gaga, Bruno Mars and Justin Bieber. Bieber, Taylor Swift, Eminem, Rihanna and Gaga all face off for the night's big honor of Top Artist. As for the Top New Artist category, Bieber will be up against Taio Cruz, Ke$ha, Bruno Mars and Nicki Minaj.
Beyoncé will be honored with the Billboard Millennium Award as she amps up to drop her forthcoming album 4. Billboard named Beyoncé their Woman of the Year in October 2009 and Top Female Artist of the Decade in December 2009. This year, she will be honored for her work both as a solo artist and as a founding member of Destiny's Child.