He's a chameleon able to blend in seamlessly against any background, but Rango's latest transformation might be his best yet: box office champ.

Led by Johnny Depp and an all-star cast of voice actors, "Rango" topped all comers at the Friday night box office with an estimated $9.75 million from 3,917 screens. Should form hold, the Gore Verbinski animated western about a chameleon who finds himself leading the small desert town of Dirt as sheriff will corral upwards of $40 million for the weekend and another number one opening from the team behind the first three "Pirates of the Caribbean" movies.

The secret to the film's success? There's a little Rango in all of us, Depp told MTV News.

"What I saw early on with the character, and something that Gore and I talked about, is that it is in sort of all of us, in a way," Depp explained. "There is a chameleonic side to all of us in which we find ourselves in certain situations that you have to adapt to."

Trailing in second place, "The Adjustment Bureau" managed to nab $6.6 from 2,840 theaters. Based on a story by acclaimed author Philip K. Dick, the Matt Damon and Emily Blunt actioner was no doubt buoyed by a largely positive response from critics.

But while "Rango" and "The Adjustment Bureau" soared, two new releases aimed at the young adult market languished. A modern day update of the classic fairy tale about the ultimate "opposites attract" couple, "Beastly" managed just $3.5 million to wind up in third place. The Alex Pettyfer and Vanessa Hudgens starring flick should wind up with approximately $10 million for the weekend.

After languishing on the shelf for years, "Take Me Home," meanwhile, scored just $1.2 million on Friday. Starring Topher Grace and Anna Faris, the flick might slip out of the top ten come Monday.

Rounding out the top five, "Hall Pass" and "Just Go With It" managed $2.7 million and $1.9 million, respectively. Among other films in the top ten, "The King's Speech" followed up its four wins at the Academy Awards with a $1.6 million Friday.