When she nabbed the first two Moonmen of the night on Sunday, she brought the American military's controversial "Don't ask, Don't tell" policy into the limelight. Gaga gave a shout-out to "all the gays for remixing this video over and over," when "Bad Romance" snagged Best Female Video. And when she was handed the coveted Video of the Year for the song, she revealed the title of her hotly anticipated third effort, Born This Way, and even belted out a lyric.
Throughout her many trips to the stage, an emotional Gaga teared up and set off flashbulbs with a meat-themed frock.
But that was just one evening. Here's a look at some of Lady Gaga's most memorable stage-show statements:
»In August 2009, the singer riled up the crowd at a Tel Aviv show, abandoning few of the outrageous antics she'd promised to avoid days before. "Tel Aviv, get your di--s out, because I heard there's some pretty big co--s here in Israel," Gaga said.
»Donning a mask and jagged crown constructed from blood-red lace, Gaga triumphantly clutched her Best New Artist award at the 2009 VMAs. "It's my first f---ing Moonman," Gaga bellowed. She capped off a night of head-turning fashion and a jaw-dropping stage set by announcing the win is "for God and the gays."
»Gaga continued to work it for "the gays" when she performed at the Human Rights Campaign dinner in October by switching up the lyrics to John Lennon's "Imagine." "Imagine there's no heaven/ It's easy if you try," Gaga sang before referencing the tragic murder of Matthew Shepard, "No hell below us/ And only Matthew in the sky."
»Although she didn't accept the awards onstage at the 2010 Grammy Awards in February, Gaga tweeted a picture of herself in tears after learning she had landed statuettes for Best Dance Recording and Best Electronic/Dance Album.
»Later on in the month, Gaga paid tribute to her late friend, designer Alexander McQueen, at the 2010 Brit Awards, saying, "Thank you to Lee McQueen," while sporting an intricate white lace headpiece and rocking a towering blonde wig.
» Gaga spoke out against Arizona's controversial SB 1070 immigration bill during a Monster Ball Tour stop in Phoenix: "I will not cancel my show. I will hold you, and we will hold each other, and we will protest this state."
The Moonmen have all been handed out and the stars have gone home, but there's plenty of 2010 MTV Video Music Awards news, interviews, behind-the-scenes scoop, party reports and more still to come, so keep it locked on MTVNews.com.