The 2010 MTV Video Music Awards will feature yet another epic battle: Lady Gaga leading the nominations, with 13, followed close behind by Eminem, who has eight nods. And on September 12 at at 9 p.m ET, the pop diva and the Detroit MC will go head to head for the coveted Video of the Year Moonman.

Gaga will certainly be a dominant presence at the show, thanks to her nods in categories like Best Pop Video, Best Female Video and Best Dance Music Video for "Bad Romance." Gaga is the first female artist to be nominated for Video of the Year twice, for "Bad Romance," as well as her collaboration with Beyoncé, "Telephone."

"I'm so honored for all the little monsters and self-professed freaks of the universe, to have more VMA nominations in a single year than any artist in MTV history. Ironically, I'm even more proud it's an unlucky number: 13," Lady Gaga said. "A long time ago, the world told me and my little monsters we would never be heard. Together we changed the rules. God put me on Earth for three reasons: to make loud music, gay videos and cause a damn raucous. Thank you, MTV!"

Eminem, whose "Not Afraid" video is up for Video of the Year, will try to fend off his competition in categories like Best Male Video and Best Hip-Hop Video. Plus, he's nominated alongside Drake in Best Hip-Hop Video for his contribution to the MC's cameo-filled "Forever."

"Apparently, MTV doesn't care that I have two massive stadium shows on the other side of the country the day after the VMAs. F me, right?!?!" Eminem joked. "I mean, I'll be there, but don't expect me to be nice about it."

Also nominated for Video of the Year are Florence and the Machine ("Dog Days Are Over"), 30 Seconds to Mars ("Kings and Queens") and B.o.B featuring Hayley Williams ("Airplanes").

Katy Perry's ode to her home state "California Gurls," featuring Snoop Dogg, is up for Best Female Video, along with Ke$ha's "Tik Tok"; "Video Phone" with Gaga and Beyoncé; Taylor Swift's "Fifteen" and Gaga's "Bad Romance."

In Best Male Video, Usher's epic "OMG" lands a nod, as well as Jason Derulo's "In My Head," Drake's "Find Your Love," Em's "Not Afraid" and B.o.B's "Airplanes."

Many of the pop world's recent favorites will face off in the Best New Artist category. Justin Bieber ("Baby"), Ke$ha ("Tik Tok"), Jason Derulo ("In My Head"), Nicki Minaj (for her Sean Garrett collabo "Massive Attack") and indie supergroup Broken Bells ("The Ghost Inside") will see who can dominate as this year's reigning newbie.