Great movies often deal with topics that touch the heart, challenge the mind, inspire the spirit. They tell of courageous souls that lift humanity to new levels, underdogs who beat the odds, geniuses who change the world.

And then there are movies about getting laid for the first time. In the latest installment in this proud genre, Steve Carell plays Andy Stitzer, "The 40 Year-Old Virgin." It's (obviously) a comedy, albeit one laced with a bit of sadness. Loss-of-virginity movies can be love stories, but they're usually not. Perhaps because, in all honesty, it's rare that love and this red-letter moment in a person's life go hand-in-hand.

In early cinema, while sex was certainly evident at least as subtext, the topic of relinquishing virginity was taboo. Witness the furor that erupted over the 1956 film, "Baby Doll." With a screenplay by Tennessee Williams (his first original effort for film), this Elia Kazan movie tells the tale of a teenage bride (Carroll Baker) who's holding onto her virtue until she turns 20, much to the agonized frustration of her much older husband. Kazan favorite Karl Malden plays hubby Archie Lee, a struggling cotton plantation owner who is further emasculated by having to compete for both business and the physical, affections of Baby Doll, with a charming new man in town (Eli Wallach).

The movie was denounced by the Catholic Legion of Decency (of which, if memory serves, Aquaman is a member), trounced by many critics (Time magazine called it the "dirtiest American-made" movie ever released), distribution was severely limited (77 percent of theaters canceled their showings) and even today, the movie isn't in print on DVD.

The uproar was only slightly less vocal when Stanley Kubrick turned Vladimir Nabokov's "Lolita" into a movie in 1962. While the story of a middle aged man's consuming sexual obsession with his teenage stepdaughter was far more prurient than "Baby Doll," audiences were becoming a bit more inured to controversial content. Nevertheless, the storyline remains taboo; as recently as 1997, a remake by director Adrian Lyne had difficulty finding a distributor.

Editor's Picks: First-timers
In contrast, the 1971 movie "The Summer of '42" presented a misty, rosewater-colored tale of a teenage boy's escort into manhood via a sad war widow, played with alluring sensitivity by Jennifer O'Neill. O'Neill seems far older than her 22 years, due to the movie's use of first-person narrative via the young, impressionable horndog protagonist, Hermie (no, not the misfit elf, but a real boy played by Gary Grimes). There was no outcry, however, over a boy being introduced to the world of sex by a woman; it's the old double standard.

In 1980's "Little Darlings," two 15-year-old girls compete at summer camp to see who can lose her virginity first. Audiences were a bit startled by the casting of two beloved child stars, Kristy McNichol and Tatum O'Neal, as the girls. Despite the prurient premise, the movie is revered by many girls (now grown women) who came of age in that era for its realistic, multi-layered portrayal of the often difficult decision to have sex for the first time. Equally amazing is that there wasn't a machete-wielding serial killer lurking around the camp to dispatch the libidinous teens!

The early '80s saw a raft of teenage virginity films, starting with the "Citizen Kane" of the genre: "Porky's." In the 1982 comedy, a group of horny Florida teenagers descend upon a redneck brothel where they're beaten and robbed. They subsequently plot elaborate revenge while never losing sight of their ultimate goal. "Porky's" is almost universally reviled by critics and watchdogs, but in retrospect, it's practically charming. (Director Bob Clark next made the beloved holiday classic, "A Christmas Story").

That same year saw "The Last American Virgin," another teen film that utilized the template of the diverse gang of guy pals trying to score. What separates this film from the pack is that, in the end, our hero fails to "become a man."

The same can't be said of a young Tom Cruise in 1983's "Losin' It," a period piece set in the mid-'60s about a group of teenage California guys who travel to Mexico to ... well, look at the title. Along the way, they pick up a runaway bride ("Cheers" barmaid Shelley Long), who ends up being the lady who deflowers everyone's favorite wacky Scientologist (playing a character named "Woody," no less).

Perhaps the darkest tale of virginity lost is Choderlos de Laclos' scandalous 18th-century novel, "Les Liaisons Dangereuses," a story of decadence among the French ruling class. A cad named Vicomte Sebastien de Valmont gets his kicks by seducing young and/or chaste girls by any means necessary, sometimes with the aid of his ex-lover, the equally repulsive Marquise Isabelle de Merteuil. Inevitably, things get messy.

The story has been adapted to film and TV many times, first by Roger Vadim in the 1959 film, "Les Liaisons Dangereuses," which set the film in contemporary France and made Valmont and Merteuil a married couple trying to bed people at a ski resort. In 1988, Stephen Frears directed a more literal translation, "Dangerous Liaisons" starring John Malkovich and Glenn Close as the scheming pair and Michelle Pfeiffer and Uma Thurman as two of their victims. The very next year, Milos Forman's "Valmont" (with Colin Firth and Annette Bening as the lead terrors) told the same story.

Debates rage as to which is the best film, with a few non-traditionalists voting for 1999's "Cruel Intentions" setting the story in modern-day New York, with a hot young cast including Ryan Phillippe (Valmont), Sarah Michelle Gellar (playing Merteuil as Valmont's step-sister), Reese Witherspoon and Selma Blair. With a version for every sensibility, this brutal cautionary tale should be required viewing for anyone who thinks that playing games with someone's heart (especially when sex becomes part of the equation) is harmless fun.

Despite many claims of our culture becoming more debased than ever, one could make the argument that, in fact, there's more morality in pop culture than ever before. Take "American Pie" (1999), the most recent progeny of "Porky's." Yes, it's about a bunch of guys who are driven to lose their virginity before prom, but in the end, they all learn about the consequences — in addition to the joys of sex. Despite being more forward with the jokes (can anyone ever hear the phrase "band camp" without getting specific imagery regarding Alyson Hannigan and a flute?), the film really does have a moral center. It might not be the kind of unrealistic morality that many who bury their heads in the sand would prefer; but it's a realistic depiction of a very human drive, one that is never, ever going to go away.

The fact is, in almost everyone's life, virginity eventually becomes a pressing issue, and it's usually fraught with some degree of anxiety. To keep or not to keep? Movies like "Stealing Beauty" (1996), "American Virgin" (2000), "Fat Girl" (2001) and even "Elizabeth" (about the 16th-century reign of Elizabeth I, England's so-called "Virgin Queen") powerfully depict the accompanying angst, illustrating how often a woman's identity, for better or for worse, is linked to her sexuality.

For guys, of course, there's usually no real anxiety regarding virginity: It's almost always "not to keep." The angst only arrives if the goal isn't met. It's hard to imagine a comedy mocking a middle-aged woman for never having had sex, but such is the world we live in. And if "The 40 Year-Old Virgin" ends with Andy's virtue still intact? Well, at least he has his action figure collection.

Check out everything we've got on "The 40 Year-Old Virgin."

Visit Movies on MTV.com for Hollywood news, interviews, trailers and more.