Chemistry is a funny thing. Some couples have it, some couples don’t. If the trailer for "Friends with Benefits" is any indication, Justin Timberlake and Mila Kunis most definitely have that special something. It doesn't hurt that they’re both madly attractive stars with banging bodies.
In honor of this sexy pairing -- thank you, casting gods! -- we've compiled our picks for the hottest on-screen couples to grace the silver screen this century (ie, since 2000). Guys, loosen up that collar. Ladies, turn on that AC.