It will all happen Tuesday, January 31st on MTV and MTV.com. MTV News' Josh Horowitz will sit down with the Academy Award-winning actress for an interview and premiere a never-before-seen clip from "This Means War" starting at 7:56 pm EST on MTV. Immediately afterward, the interview continues for 30 minutes over on MTV.com.
Maybe you want to know what it's like to have Chris Pine and Tom Hardy fighting over her in "This Means War." Or perhaps you have a nagging Robert Pattinson question you've been pondering since "Water For Elephants." Whatever your burning question may be, Witherspoon could answer it.
All you have to do is sent a text or video question via MTV.com or Twitter, using @MTVNews with the hashtag #MTVFirst.
So start asking now, and tune in next week to see if you get the answer you've been looking for.