Depp might be known best for his wacky onscreen personalities, like Captain Jack Sparrow in the "Pirates of the Caribbean" series, but he plays guitar pretty well, too.
He played lead on Manson's hit song "The Beautiful People" during a Halloween concert at the Roxy in Hollywood. Manson also invited rapper Ninja of the South African hip-hop group Die Antwoord to join him on vocals.
Watch footage of the band's star-studded performance below.
The two celebs have apparently been pals for a while—they recorded a version of Carly Simon's classic "You're So Vain" together back in 2012. Manson also previously worked with Depp by providing the song “The Nobodies” for Depp's film about Jack the Ripper "From Hell."
And of course, there was that time back in 2012 when Johnny jammed with The Black Keys for the MTV Movie Awards.
He was so good that Dan Auerbach and Patrick Carney joked about starting a band with him. And come to think of it, we haven't heard that much from Depp since "Transcendence" came out earlier this year, have we? Maybe he's off working on his musicianship. Drop an album Johnny, I'd definitely listen!