Chelsea Handler, Kathy Griffin Defend Their Comedy

'When you act irresponsibly like Lindsay Lohan, you're gonna get made fun of by me,' Handler says.

Chelsea Handler and Kathy Griffin have struck comedy gold over the

years poking fun at celebrities. But recently their comedic jabs have gotten the ladies into a bit of hot water: Griffin for mocking Bristol Palin's weight and Handler

for making comments about Angelina Jolie's love life.

So when the two sat down on Handler's E! talk show, they aruged that while people may take offense at their words, what they are doing isn't bullying. "There's a big difference between being a comedian and bullying," Griffin said when she appeared on "Chelsea Lately" on Thursday night.

The show's host agreed, noting, "Bullying is being a bully to someone who's defenseless, a poor little person who's done nothing wrong, not the people who are a--holes. When you act irresponsibly and run around the world like Lindsay Lohan, you're gonna get made fun of by me."

It's not the first time Handler has defended her comedy. After footage of a recent act, during which she made some seething comments about Jolie, appeared online, she explained, "They were talking about me on 'The View,' talking about me and my Angelina Jolie tirade. Can I just say that I've been making fun of Angelina Jolie since she made out with her brother?" she remarked. "If I've learned nothing from this, it's to write new jokes."

For those wondering what Handler's beef is with Jolie, the comedian is pals with Jennifer Aniston, who was married to Brad Pitt before he hooked up with Jolie.