‘Love And Other Drugs’ Co-Stars Have Chemistry On (And Off) Screen

'Just wait, she's going to say something amazing,' Jake Gyllenhaal gushes about Anne Hathaway during MTV News interview.

Much of the advance buzz about Anne Hathaway and Jake Gyllenhaal’s “Love and Other Drugs” has centered on the film’s nudity — the co-stars bare some serious skin in a few key moments — but the actors’ chemistry is another important element in the movie.

Actors will typically declare how well the cast and crew got along on set when promoting a movie, whether it’s true or not. But in the case of Hathaway and Gyllenhaal, it seemed obvious the two share a genuine mutual affection, as MTV News learned when we caught up with them to discuss their romantic comedy, which opens Wednesday. Since Hathaway and Gyllenhaal have collaborated onscreen before, we asked what it was like to do press together.

“[She's] annoying,” Gyllenhaal joked about having to sit side-by-side for interviews all day. Then, turning serious, he added, “She’s so dope at press. Can we talk about this for a second? She’s got a rare talent at ‘pressing’ it.”

“How dare you set me up at the beginning of an interview like that?” Hathaway interjected in mock protest. “How dare you!”

“Your mind is going to be blown by this chick,” Gyllenhaal continued.

“Wait, he’s about to say the smartest thing you’ve ever heard!” Hathaway countered.

“No, just wait, she’s going to say something amazing and you’re going to be moved, you’re going to cry,” Gyllenhaal enthused. “There’s going to be something you’ve never felt before.”

The onetime “Brokeback Mountain” co-stars then began talking over each other, spouting off various compliments.

“No, Jake’s great. Jake’s awesome,” Hathaway said as Gyllenhaal echoed the warm fuzzy sentiments.

“She’s so talented. She’s at the top of her game. Everything about her is so special,” he said.

“It’s so nice to know that someone really has your back,” she said.

“She’s so beautiful right now,” he said, which got Hathaway’s attention.

“Oh, thank you,” she said, turning to her co-star. “I think you’re just really handsome!”

“Her body is gorgeous in the film,” Gyllenhaal continued.

“Well, that’s too far,” Hathaway said.

Check out everything we’ve got on “Love and Other Drugs.”

For young Hollywood news, fashion and “Twilight” updates around the clock, visit HollywoodCrush.MTV.com.