John Barrymore (Don Jose de Marana/Don Juan de Marana)
Mary Astor (Adriona Della Varnese)
Willard Louis (Perdillo)
Estelle Taylor (Lucretia Borgia)
Warner Oland (Cesare Borgia)
Montagu Love (Count Giano Donati)
Gustav von Seyffertitz (Neri, the Alchemist)
Helen Lee Worthing (Eleanora)
Sheldon Lewis (Gentlemen of Rome)
Helena D'Algy (Donna Elvira, Murderess of Jose)
Gibson Gowland (Gentlemen of Rome)
Emily Fitzroy (The Dowager)
Nigel de Brulier (Marchese Rinaldo)
Dick Sutherland (Gentleman of Rome)
John Roche (Leandro)
June Marlowe (Trusia)
Yvonne Day (Don Juan, at Age 5)
Philippe DeLacy (Don Juan, at Age 10)
John George (Hunchback)
Lionel Braham (Duke Margoni)
Phyllis Haver (Imperia)
Hedda Hopper (Marquise Rinaldo)
Myrna Loy (Mai, Lady in Waiting)
Helene Costello (Rena, Adriona's Maid)
Jane Winton (Donna Isobel)