Johnny Depp (William Blake)
Gary Farmer (Nobody)
Lance Henriksen (Cole Wilson)
Michael Wincott (Conway Twill)
Robert Mitchum (John Dickinson)
Mickey McGee (Bartender (Uncredited))
John C. Pattison (Trading Post Man No. 1)
Gibby Haines (Man with Gun in Alley)
George Duckworth (Man at End of Street)
Thomas Bettles (Young Nobody)
Daniel Chas Stacy (Young Nobody)
Leonard Bowechop (Makah Villager)
Cecil Cheeka (Makah Villager)
John North (Mr. Olafsen)
Johnny Pfeiffer (Man at Trading Post)
Todd Pfeiffer (Trading Post Man No. 2)
Mike Dawson (Old Man with Wanted Posters)
Mark Bringelson (Lee, Younger Marshall)
Eugene Byrd (Johnny "The Kid" Pickett)
Jared Harris (Benmont Tench)
John Hurt (John Scholfield)
Alfred Molina (Trading Post Missionary)
Pete Schrum (Drunk)
Billy Bob Thornton (Big George Drakoulious)
Michelle Thrush (Nobody's Girlfriend)
Jimmie Ray Weeks (Marvin, Older Marshall)
Michael McCarty (Makah Villager)
Richard Boes (Man with Wrench)
Mili Avital (Thel Russell)
Gabriel Byrne (Charlie Dickinson)
Iggy Pop (Salvatore "Sally" Jenko)
Crispin Glover (Train fireman)