Andie MacDowell (Ann Finnegan)
Robert Downey, Jr. (Bill Bush)
Madeleine Stowe (Sherri Shepard)
Lily Tomlin (Doreen Piggot)
Tom Waits (Earl Piggott)
Frances McDormand (Betty Weathers)
Peter Gallagher (Stormy Weathers)
Annie Ross (Tess Trainer)
Lori Singer (Zoe Trainer)
Bruce Davison (Howard Finnigan)
Tim Robbins (Gene Shepard)
Lyle Lovett (Andy Bitkower)
Buck Henry (Gordon Johnson)
Huey Lewis (Vern Miller)
Chris Penn (Jerry Kaiser)
Julianne Moore (Marian Wyman)
Anne Archer (Claire Kane)
Matthew Modine (Dr. Ralph Wyman)
Fred Ward (Stuart Kane)
Jack Lemmon (Paul Finnegan)
Jennifer Jason Leigh (Lois Kaiser)
Lili Taylor (Honey Bush)
Michael Beach (Jim Stone)
Jane Alden (Mrs. Schwarzmeier)
Dirk Blocker (Diner Customer)
Jay Della (Bartender)
Robert DoQui (Knute Willis)
Jerry Dunphy (Himself)
Debbie Falconer (Barbara)
Jarrett Lennon (Chad Weathers)
Charles Rocket (Wally Littleton)
Natalie Strong (Mourner)
Alex Trebek (Himself)
Darnell Williams (Joe Robbins)
Danny Darst (Aubrey Bell)
Andi Chapman (Harriet Stone)
Greg Cohen (The Low Note Quintet #3)
Susie Cusack (Nancy)
Terry Adams (The Low Note Quintet #1)