Though filmed ten years after The Saint Meets the Tiger, the British The Saint's Girl Friday is generally regarded as the final entry in RKO's "Saint" series of 1938-43. Louis Hayward, who first played Leslie Charteris' soldier-of-fortune Simon Templar in the 1938 film The Saint in New York, returns to the role after a 16-year absence. This time, Templar comes to London at the invitation of an old female acquaintance. When he arrives, he discovers that the woman is dead, the possible victim of a vicious gambling syndicate. Together with chronic gambler Carol Denby (Naomi Chance), who is being blackmailed into acting as a come-on for the crooks, Templar takes on chief heavy Max Lennar (Sidney Taffler), all the while keeping one step ahead of Scotland Yard inspector Teal (Charles Victor). ~ Hal Erickson, All Movie Guide