Meryl Streep (Kay)
Tommy Lee Jones (Arnold)
Steve Carell (Doctor Feld)
Jean Smart (Eileen, Kay's friend)
Ben Rappaport (Brad, their son)
Elisabeth Shue (Karen, the bartender)
Charles Techman (Charlie, the docent)
Daniel Flaherty (Danny, the bookstore clerk)
Damian Young (Mike, the innkeeper)
Mimi Rogers (Carol, the neighbor)
Ann Harada (Ann, the happy wife)
Jack Haley (Jack, the happy husband)
Susan Misner (Dana, Doctor Feld's Wife)
Rony Clanton (Ronnie, the taxi driver)
John Srednicki (John, the waiter)
Madeline Ruskin (Maddie, Brad's girlfriend)
Lee Cunningham (Lee, the unhappy wife)
Paul Letersky (Paul, the unhappy husband)
Rogina Bedell-O'Brien (Rogina, the exiting patient)
Stephen Lee Davis (Steve, the grocery shopper)
Marin Ireland (Molly, their daughter)
Patch Darragh (Mark, their son-in-law)
Brett Rice (Vince, Arnold's friend)
Becky Ann Baker (Cora, the waitress)