Ed Helms (Tim Lippe)
John C. Reilly (Dean Ziegler)
Anne Heche (Joan Ostrowski-Fox)
Isiah Whitlock, Jr. (Ronald Wilkes)
Mike O'Malley (Mike Pyle)
Sigourney Weaver (Macy Vanderhei)
Inga Wilson (Gwen Lemke)
Mike Birbiglia (Trent)
Seth Morris (Uncle Ken)
Christopher Lemon (Rock Climbing Dude #1)
Sudhi Rajagopal (Rock Climbing Dude #2)
Chris DiAngelo (Kurt Gambsky)
Lindsey Alexandra Hartley (Pam Gambsky)
Welker White (Dione Krogstad)
John Djurovski (Bartender)
Charlie Sanders (TSA Agent)
Craig Janos (Jack Nicholson Impersonator)
Tracey Maloney (Flight Attendant)
Steve Blackwood (Lindy)
Carl Harry Carlson (Older Man)
Kenneth Wood (Waiter)
Lisa Lacasse (Lila)
James Howard Carr (Swarthy Man)
David Rhoads (Ball Pit Judge)
Bruce Giffin (Photographer)
Teresa Yenque (Maid)
Helen-Jean Arthur (Church Lady)
Michael Tuba Heatherton (Plate Spinner)
Leisa Pulido (Talent Show MC)
Ed Jewett (Bearded Dude)
Zackary Hamlin (Clem)
Kimberly Moncrieff (Small Woman)
Linda Riker (Small Woman's Friend)
Michael Buie (Brian Early)
Roz Music (Lady)
Loit Maripuu (Customer #3)
Bruce Lawson (Customer #4)
Ian Minicuci (Perry (Man in Wheelchair))
Penny Gibbs (ASMI Representative)
Victor Pytko (Merle Huss)
Sandy Gittleson (Sherri Fahrenkrug)
Richard L. Fox (Hotel Employee)
John F. McCormick (Dad)
Joanne McGee (Mom)
Stephen Root (Bill Krogstad)
Hayley Zeccardi (Daughter)
Kurtwood Smith (Orrin Helgeson)
Alia Shawkat (Bree)
Thomas Lennon (Roger Lemke)
Rob Corddry (Gary)