Danny Trejo (Machete)
Robert De Niro (Sen. McLaughlin)
Jessica Alba (Sartana)
Steven Seagal (Torrez)
Michelle Rodriguez (Luz)
Lindsay Lohan (April)
Tom Savini (Osiris Ampanpour)
Daryl Sabara (Julio)
Gilbert Trejo (Jorge)
Billy Blair (Von's Henchman)
Ara Celi (Reporter)
Feliz Sabates (Doc Felix)
Electra Avellan (Nurse Mona)
Elise Avellan (Nurse Lisa)
Marci Madison (Nurse Fine)
Vic Trevino (Federale Officer)
Mayra Leal (Chica (Naked Girl))
Alejandro Antonio (Chief)
Juan Pareja (Rico)
Alicia Marek (June)
Jason Douglas (Patrolman #1)
Mitchell Lance Adams (Patrolman #2)
Brent Smiga (Sniper's Henchman)
Chris Warner (Hospital Security Guard)
Jim Henry (Guard)
Tina Rodriguez (Tristana)
Roland Ruiz (Luis)
Greg Ingram (Cristos)
Tito Larriva (Culebra Cruzado)
Cheryl "Chin" Cunningham (Torrez Henchwoman)
Hugo Perez (Driver (Van))
Nina Leon (Machete's Wife)
Doran Ingram (Von's Minute Man)
James Brownlee (Henchman)
Nimród Antal (Booth's Bodyguard #1)
Al "Train" Dias (Bodyguard #2)
Dimitrius Pulido (Bodyguard #3)
Scott Jefferies (Bodyguard #4)
Edgar Arreola (Dishwasher #1)
Tommy Nix (Dishwasher #2)
Jeff Fahey (Booth)
Cheech Marin (Padre)
Don Johnson (Von)
Shea Whigham (Sniper)