Bob Hoskins (Eddie Valiant)
Christopher Lloyd (Judge Doom)
Joanna Cassidy (Dolores)
Charles Fleischer (Roger Rabbit)
Stubby Kaye (Marvin Acme)
Charles Fleischer (Greasy)
Alan Tilvern (R.K. Maroon)
Jim Cummings (Bullet)
Joel Cutrara (Forensic)
Sadie Corré
Michael Edmonds (Midget)
Peter Diamond
April Winchell (Mrs. Herman)
James O'Connell (Conductor)
Paul Springer (Augie)
Laura Frances (Blonde Starlet)
Jim Gallant (Bullet)
Eugene Guirterrez (Teddy Valiant)
Christopher Hollosy (Kid)
Fred Newman (Stupid)
Les Perkins (Toad)
Mary T. Radford (Hippo)
Eric B. Sindon (Mailman)
John-Paul Sipla (Kid)
Del Baker
Richard Ridings (Angelo)
Charles Fleischer (Benny the Cab)
Chris Fleischer
Charles Fleischer (Psycho)
Edwin Craig (Arthritic Cowboy)
Danny Capri (Kid)
Pat Buttram (Bullet)
Andrew Bradford
Mel Blanc (Tweety Bird)
Mel Blanc (Sylvester)
Mel Blanc (Porky Pig)
Mel Blanc (Bugs Bunny)
Ed Herlihy (Newscaster)
Billy Mitchell (Forensic)
David L. Lander (Smart Ass)
Lindsay Holiday (Soldier)
Amy Irving (Jessica Rabbit's (Singing))
Lou Hirsch (Baby Herman)
Mel Blanc (Daffy Duck)
Morgan Deare (Editor, Bongo the Gorilla)
Mae Questel (Betty Boop)
Tony Anselmo (Donald Duck)
Joe Alaskey (Yosemite Sam)
June Foray (Wheezy, Lena Hyena)
Richard Williams (Droopy)
Wayne Allwine (Mickey Mouse)
Russie Taylor (birds)
Russie Taylor (Minnie Mouse)
Tony Pope (Goofy, Wolf)
Cherry Davis (Woody Woodpecker)
Peter Westy (Pinocchio)
Frank Sinatra (Singing Sword)
Richard Le Parmentier (Lt. Santino)
Joel Silver (Raoul Raoul, Director)
Betsy Brantley (Jessica Rabbit, performance model)
Kathleen Turner (Jessica Rabbit (uncredited))