Debra Winger (Emma Greenaway)
Shirley MacLaine (Aurora Greenaway)
Jack Nicholson (Garrett Breedlove)
Jeff Daniels (Flap)
John Lithgow (Sam Burns)
Alexandra O'Karma (Jane)
Paul Menzel (Dr. Maise)
Michelle Watkins (Woman)
Charles Beall (Rudyard's Employer)
Sharisse Baker-Bernard (Lee Anne)
Kate Charleson (Janice)
Albert Brooks (Rudyard)
Judith Dickerson (Checkout Girl)
Mary Kay Place (Doris)
Tara Yeakey (Baby Melanie)
David Wohl (Phil)
Shane Serwin (Young Tommy Horton)
F. William Parker (Doctor)
Megan Morris (Melanie)
Nancy Mette (Woman at Party)
Jennifer Josey (Young Emma Greenway)
Betty King (Rosie)
Norman Bennett (Edward)
Huckleberry Fox (Teddy)
Troy Bishop (Tommy)
Danny DeVito (Vernon)
Lisa Hart Carroll (Patsy)