Dana Ivey (Claire)
Tom Hanks (Sam Baldwin)
Rob Reiner (Jay)
Meg Ryan (Annie Reed)
Bill Pullman (Walter)
Ross Malinger (Jonah Baldwin)
Rosie O'Donnell (Becky)
Victor Garber (Greg)
Juliet Taylor (Actor/Actress)
Sarah Trigger (Actor/Actress)
Brian McConnachie (Bob)
Tom Riis Farrell (Rob)
Tom McGowan (Keith)
La Tanya Richardson (Harriet)
Julie Janney (Cynthia)
Linda Wallem (Loretta)
Matt Smith (Mailman)
Kevin O'Morrison (Cliff Reed)
Frances Conroy (Irene Reed)
Philip Levy (Taxi Driver)
David Hyde Pierce (Dennis Reed)
Tom Tammi (Harold Reed)
Calvin Trillin (Uncle Milton)
John Boylan (Elevator Man)
Le Chance DuRand (Barbara Reed)
Rich Hawkins (Jessica's Father)
Hannah Cox (Jessica's Mother)
Donald Lee (Seattle Detective)
Victor Morris (Seattle Maitre D')
Diane Sokolow (Tiffany Saleswoman)
Sidney Armus (Information Booth Man)
Caroline Aaron (Dr. Marcia Fieldstone)
Michael Badalucco (New York Taxi Dispatcher)
Jeff Mazzola (New York Taxi Dispatcher)
Carey Lowell (Maggie Baldwin)
Gaby Hoffmann (Jessica)
Rita Wilson (Suzy)
Barbara Garrick (Victoria)