Matthew Broderick (Despereaux)
Robbie Coltrane (Gregory)
Frances Conroy (Antoinette)
Tony Hale (Furlough)
Ciarán Hinds (Botticelli)
James Nesbitt
Christopher Lloyd (Hovis)
William H. Macy (Lester)
Justin Long
Charles Shaughnessy (Pietro)
Stanley Tucci (Boldo)
Tracey Ullman (Miggery Sow)
Emma Watson (Princess Pea)
Sigourney Weaver (Narrator)
Dustin Hoffman (Roscuro)
Richard Jenkins (Principal)
Kevin Kline (Andre)
Frank Langella (Mayor)