Denzel Washington (Frank Lucas)
Russell Crowe (Richie Roberts)
Chiwetel Ejiofor (Huey Lucas)
Cuba Gooding, Jr. (Nicky Barnes)
Josh Brolin (Det. Trupo)
Albert Jones (Terrence Lucas)
J. Kyle Manzay (Dexter Lucas)
Warner Miller (Melvin Lucas)
Hamilton Clancy (Seller)
John Hawkes (Freddie Spearman)
RZA (Moses Jones)
Lymari Nadal (Eva)
Yul Vázquez (Alfonse Abruzzo)
Ruby Dee (Mama Lucas)
Idris Elba (Tango)
Carla Gugino (Laurie Roberts)
Joe Morton (Charlie Williams)
Common (Turner Lucas)
Jon Polito (Rossi)
Kevin Corrigan (Campizi)
Roger Guenveur Smith (Nate)
Malcolm Goodwin (Jimmy Zee)
Ric Young (Chinese General)
Roger Bart (U.S. Attorney)
Tip "T.I." Harris (Stevie Lucas)
KaDee Strickland (Richie's Attorney)
Ruben Santiago-Hudson (Doc)
Norman Reedus (Detective in Morgue)
Ted Levine (Lou Toback)
Armand Assante (Dominic Cattano)
Clarence Williams III (Ellsworth "Bumpy" Johnson)
John Ortiz (Javier J. Rivera)