Paul Rudd (Jeff Reigert)
Oliver Platt (Marc Jacobson)
Ken Marino (Dr. Glenn Richie)
Kerri Kenney-Silver (Bernice Jaffe)
Famke Janssen (Gretchen Reigert)
Gretchen Mol (Gloria Jennings)
Winona Ryder (Kelly La Fonda)
Jessica Alba (Liz Anne Blazer)
Adam Brody (Stephen Montgomery)
Rob Corddry (Duane Rosenblum)
Justin Theroux (Jesus H. Christ)
Liev Schreiber (Ray Johnson)
Charlie McDermott (Jake Johnson)
Zandy Hartig (Sally Johnson)
Joe Passaro (Xylophone Player Clovis Handleman)
Reed Birney (Jim Stansel)
John Tormey (Junkie Jerry Park)
Michael Showalter (Police Lt. Flarn Bleern)
Zak Orth (Prosecutor/Tour Guide Barge Michaelson)
Rashida Jones (Hostess Rebecca Fornier)
David Wain (Abe Grossman)
Jerry Grayson (Junkie Floyd Congril Dillon)
Jason Antoon (Salazar "Fred" McBairn)
Janeane Garofalo (Nuclear Power Plant Shift Supervisor Beth Soden)
Michael Ian Black (Prison Guard Jambert Saivon)
A.D. Miles (Oliver Jennings)
Thomas Lennon (Scotty Pale)
Joe Lo Truglio (Paul Mardino)
Mather Zickel (Louis La Fonda)
Michael Ziegfield (Harlan Swallow)
Jason Sudeikis (Tony Contiella)
Ron Silver (Fielding Barnes)
Bobby Cannavale (Marty McBride)
Cedric Sanders (Greg Jaffe)
Arlen Escarpeta (Todd Jaffe)