Samuel L. Jackson (Lazarus Woods)
Christina Ricci (Rae)
Justin Timberlake (Ronnie)
S. Epatha Merkerson (Angela)
John Cothran, Jr. (Reverend R.L.)
Neimus K. Williams (Lincoln)
Son House (Himself)
Leonard Thomas (Deke Woods)
Ruby Wilson (Mayella)
Claude Phillips (Bojo)
Amy Lavere (Jesse)
Clare Grant (Kell)
Jeff Pope (Batson)
Charles Skip Pitts (Charlie)
Willie Hall (Pinetop)
John Malloy (Gene)
T.C. Sharpe (Archie)
John Still (Herman)
Jared Hopkins (Auto Worker)
Tosh Newman (Conner)
Cody Block (Bryan)
Benjamin Rednour (Guardsman)
Carnell Pepper (Melvin)
David Chapman (Red)
Jolynne Palmer (Ella Mae)
Raymond Neal (Herschel)
John Pickle (Arty)
Kim Justis (Waitress)
Cedric Burnside (Himself)
Kenny Brown (Himself)
David Banner (Tehronne)
Michael Raymond-James (Gill)
Adriane Lenox (Rose Woods)
Kim Richards (Sandy (Rae's Mother))