Paul Reubens (Pee-Wee Herman)
Elizabeth Daily (Dottie)
Mark Holton (Francis)
Diane Salinger (Simone)
Judd Omen (Mickey)
Zachary Hoffman (Director)
Bill Cable (Policeman)
Patrick Cranshaw (Hobo)
Brett Fellman (Kid)
Richard Brose (Tarzan)
Noreen Hennesey (Reporter)
Michael Varhol (Photographer)
Bill Richmond (Highway Patrolman)
Cassandra Peterson (Biker Mama)
John Paragon (Movie Lot Actor)
Wallis Nicita (Actor/Actress)
John Gilgreen (Policeman at Pet Shop)
Chester Grimes (Biker)
Jason Hervey (Kevin Morton)
Gregory Brown (BMX Kid)
David C. Glasser (BMX Kid)
Alex Sharp (Cowboy)
Drew Seward (Kid)
Gilles Savard (Pierre)
George Sasaki (Japanese Director)
David Rothenberg (Hobo)
John O'Neill (Cowboy)
John Moody (Bus Clerk)
Howard Hirdler (Biker)
Raymond Martino (Gang Member)
Phil Hartman (Reporter)
Peter Looney (Policeman)
Monte Landis (Mario)
Jan Hooks (Tina)
Ed Herlihy (Mr. Buxton)
Irving Hellman (Neighbor)
Ed Griffith (Trucker)
Mark Everett (BMX Kid)
Starletta DuPois (Sgt. Hunter)
Bob Drew (Fireman)
Lou Cutell (Amazing Larry)
Luis Contreras (Biker)
Simmy Bow (Man in Diner)
Damon Martin (Chip)
Susan Barnes (Movie Lot Actress)
Prof. Toru Tanaka (Butler)
Lynne Stewart (Mother Superior)
Erica Yohn (Madam Ruby)
Milton Berle (Himself [uncredited])
Ralph Seymour (Francis' Accomplice)
Daryl Roach (Chuck)
Lonnie Parkinson (Biker)
Sunshine Parker (Hobo)
Alice Nunn (Large Marge)
Bob McClurg (Studio Guard)
Twisted Sister (Themselves)
Morgan Fairchild ("Dottie")
Jon Harris (Andy)
Carmen Filpi (Hobo Jack)
Tony Bill (Terry Hawthorne)
James Brolin ("P.W.")