Max Minghella (Jerome Platz)
Sophia Myles (Audrey)
John Malkovich (Professor Sandford)
Jim Broadbent (Jimmy)
Matt Keeslar (Jonah)
Adam Scott (Marvin Bushmiller)
Jack Ong (Professor Okamura)
Michael Lerner (Art Dealer)
Katherine Moennig (Candace)
Lauren Lee Smith (Beat Girl)
Jeremy Guskin (Eno)
Jeanette Brox (Shilo)
Monika Ramnath (Flower)
Isaac Laskin (Kiss-Ass)
Scoot McNairy (Army Jacket)
Finneus Egan (Vegan)
Shelly Cole (Filthy-Haired Girl)
Jean St. James (Mom)
Cristen Coppen (Preppy Girl)
Michael Shamus Wiles (Donald Baumgarten)
Paul Collins (Professor David Zipkin)
Ezra Buzzington (Leslie (Male Model))
Kimi Reichenberg (Suburban Girl)
Alexander Ryan (Nympho)
Travis Walck (Richard Natwick)
Roxanne Hart (Mom Platz)
Osman Soykut (Dad Platz)
Katija Pevec (Cynthia Platz)
Brian Turk (Cliffy (Cousin))
Edith Jefferson (Doddering Aunt)
Roxanne Day (Marie (Jonah's Wife))
Marshall Bell (Lonny)
Marc Vann (Kevin)
Chris L. McKenna (Mikey)
Zach Maurer (Young Jerome)
Charlie Talbert (Vince's Editor)
John Bliss (Vince's Grandpa)
Ethan Suplee (Vince)
Joel David Moore (Bardo)
Nick Swardson (Matthew)
Anjelica Huston (Sophie)