Burgess Meredith (George Milton)
Lon Chaney, Jr. (Lennie)
Betty Field (Mae)
Charles Bickford (Slim)
Roman Bohnen (Candy)
Jack Lawrence (Ranch Hand)
Silver Tip Baker (Old Hand)
Baldwin Cooke
Carl Pitti
Leona Roberts (Aunt Clara)
John Beach (Ranch Hand)
Barbara Pepper (2nd Girl)
Eddie Dunn (Bus Driver)
Howard Mitchell (Sheriff)
Leigh Whipper (Crook)
Helen Lynd (Susie)
Bob Steele (Curley)
Noah Beery, Jr. (Whit)
Oscar O'Shea (Jackson)
Granville Bates (Carlson)