Nicole Kidman (Isabel Bigelow/Samantha)
Will Ferrell (Jack Wyatt/Darrin)
Shirley MacLaine (Iris Smythson/Endora)
Michael Caine (Nigel Bigelow)
Jason Schwartzman (Richie)
Annie Mumolo (Bed Bath and Beyond Shopper)
Andrew Friedman (Bed Bath and Beyond Shopper)
Clay Bravo (Coffee Shop Waitress)
Heather Freedman (Beverly Hills Hotel Hostess)
Brittany Paige (Auditioning Actress)
Abbey McBride (Auditioning Actress)
Katie Finneran (Sheila Wyatt)
Roxanne Beckford (Francine)
Nick Lachey (Vietnam Soldier)
Mo Rocca (E! Reporter)
Alison MacInnis (Auditioning Actress)
Katharine Carroll (Auditioning Actress)
Dawn Ashley Cook (Auditioning Actress)
Molly Gordon (Trick-or-Treater)
Ruby Rose Skotchdopole (Trick-or-Treater)
Liesel Staubitz (Trick-or-Treater)
Valerie Azlynn (Gorgeous Model)
Terry Savage (Dinner Party Guest)
Julie Claire (Hillary)
Jordan Black (Press Conference Photographer)
Joe Zymblosky (Randall)
Hugh Davidson (Network Executive)
Julia Schuler (Auditioning Actress)
Wendi McLendon-Covey (E! Anchor)
Susan Chuang (Press Conference Reporter)
Jonathan T. Floyd (Cable Man)
Laura Sorenson (Auditioning Actress)
Jennifer Elise Cox (Auditioning Actress)
Victor Williams (Police Officer)
J.J. Sacha (Voice-Over Announcer)
Bridget Ann Brno (Auditioning Actress)
Jennifer Hall (Book Soup Cafe Waitress)
Carole Shelley (Aunt Clara)
Ed McMahon (Himself)
Richard Kind (Abner Kravitz)
Kenneth Hudson Campbell (Writer)
Michael Badalucco (Joey Props)
Dana Daurey (Auditioning Actress)
Kate Walsh (Sexy Waitress)
Amy Sedaris (Gladys Kravitz)
P. J. Byrne (Writer)
Jason Winston George (E! Anchor)
James Lipton (Himself)
Jarrad Paul (Valet)
Carol Androsky (Realtor)
Dianne Dreyer (Production Staff Assistant)
Dorie Barton (Auditioning Actress)
Conan O'Brien (Himself)
David Alan Grier (Jim Fields)
Steve Carell (Uncle Arthur)
Kristin Chenoweth (Maria Kelly)
Heather Burns (Nina)
Jim Turner (Larry)
Stephen Colbert (Stu Robison)