Derek Luke (Antwone Fisher)
Joy Bryant (Cheryl Smolley)
Denzel Washington (Dr. Jerome Davenport)
Salli Richardson (Berta)
Earl Billings (James)
Leo Nepomuceno (SP #1)
Sean'e La'dae (Edward)
Malcolm David Kelley (Antwone Fisher Age 7)
Vernée Watson Johnson (Annette)
Kim Johnson (Disc Jockey)
Doug Jewell (Spinoza)
Teresa Hoefke (Case Worker)
Cory Hodges (Antwone Fisher Age 14)
Lissy Gulick (Mona)
Brandon Lewis (Ray)
Jada S. Louie (Jeannette)
Mary Bradley Marable (Older Lady)
Cordell Stokes (Keith Age 5)
Ruth Stehle (Snide Clerk)
Janaya Reynolds (Young Girl #1)
Edward C. Reynolds III (Man)
Timothy Reddick (Dwight Age 8)
John Pittman Jr. (Another Clerk)
Rita Pearson (Cashier)
Rebecca Morris (Anna)
Angela Gillespie-Winborn (Woman In White)
David Fowler (Chief Master-At-Arms)
Leonard Earl Howze (Pork Chop)
Sung Kang (Receptionist)
Jascha Washington (Jesse Age 8)
Charlie Robinson (Howard)
Michelle Davison (Johnny Mae)
Ellis Williams (Reverend Tate)
O.L. Duke (Uncle Duke)
Lynne Charles (Spinoza's Wife)
Andreas Patton (Kenny)
Bob Banks (Horace)
Margaret Ford-Taylor (Eda)
Na'tasha Marie Evans (Young Girl #2)
Fran Dorsey (Owner)
Jason Dixon (Jason)
Brandon Biggins (Eddie)
Eddie Baccus (Blind Piano Player)
Linda Cevallos (Sexy Woman)
De'Angelo Wilson (Jesse Age 19)
Yolonda Ross (Elaine Pack)
Kente Scott (Kansas City)
Stephen Snedden (Berkley)
Kevin Connolly (Slim)
Viola Davis (Eva)
Rainoldo Gooding (Grayson)
Novella Nelson (Mrs. Tate)