Carole Lombard (Jane Mason)
James Stewart (Johnny Mason)
Charles Coburn (Judge Joseph Doolittle)
Lucile Watson (Mrs. Mason)
Eddie Quillan (Conway)
Arthur Gardner (Radio Operator)
Robert Strange (Doctor)
Milburn Stone (Sam)
Ivan Simpson (Simon)
Mickey Rentschler (Office Boy)
Garry Owen (Actor/Actress)
Renee Orsell (Second Cook)
John Maurice Sullivan (John Hopkin's Chemist)
Nella Walker (Actor/Actress)
Marjorie Wood (Actor/Actress)
Harry Worth (New York Hospital Chemist)
Mary Field (Indianapolis Lab Assistant)
Betty Farrington (Hospital cashier)
Mike Kilian (Actor/Actress)
Russ Clark (Actor/Actress)
Renee Orsell (Hilda)
Robert E. O'Connor (Harry - Elevator Starter)
Jack Mulhall (Radio operator)
Harlan Briggs (Judge)
Lane Chandler (Ranger)
Harry Depp (Hutch)
Raymond Bailey (Salt Lake Hospital Chemist)
Fred Fuller (Doolittle's brother)
Ruth Gillette (Blonde in Cafe)
Arthur Hoyt (Jury Foreman)
Perry Ivins (Doctor)
Gladden James (Doctor)
Carlyle Moore, Jr. (Actor/Actress)
Tom London (Ranger)
Edwin Maxwell (Messerschmidt)
Esther Dale (First Cook)
Russell Hopton (Collins)
Ward Bond (Jim Hatton)
Olin Howland (Farmer)
Fern Emmett (Farmer's Wife)
Louise Beavers (Third Cook)
Jackie Taylor (John, Jr., at Age 1)
Alma Kruger (Sister Madeline)
Ruth Weston (Eunice Doolittle)
Donald Briggs (Carter)
Harry Davenport (Dr. Healy)