John Travolta (James Ubriacco)
Kirstie Alley (Molly)
Olympia Dukakis (Rosie)
George Segal (Albert)
Abe Vigoda (Grandpa)
Bruce Willis (Mikey)
Aurelio di Nunzio (Orderly)
Zena Darawalla (Lupe)
William Britos (Home Orderly)
David Berner (Mr. Impatience)
Shirley Barclay (Nurse)
Casey B. Grant (Admitting Clerk)
Jeff Irvine (Admitting Doctor)
Andrea Mann (Salesgirl)
Daliah Novak (Carrie)
Nicholas Rice (Harry)
Douglas Tuck (Cab Stealer)
Alex Bruhanski (Street Worker)
Joan Rivers (Julie [uncredited])
Oscar B. Ramos (Hospital Worker)
Gerry Bean (Pilot Friend)
Joy Boushel (Melissa)
Twink Caplan (Rona)
Brenda Crichlow (Secretary)
Deryl Hayes (Pilot Friend)
Louis Heckerling (Lou)
Mollie Israel (Little Girl)
D.J. Jackson (Burly Orderly)
Blu Mankuma (Director)
Enid Saunders (Ester)
Neal Israel (Mr. Ross)
Jerry Wasserman (Mr. Anal)
William B. Davis (Drug Doctor)
Don S. Davis (Dr. Fleisher)
Christopher Aydon (Mikey)
Jason Schaller (Mikey)
Jaryd Waterhouse (Mikey)
Jacob Haines (Mikey)