William Bendix (George Herman "Babe" Ruth)
Claire Trevor (Claire Hodgson Ruth)
Charles Bickford (Brother Mathias)
Sam Levene (Phil Conrad)
William Frawley (Jack Dunn)
Oliver Crawford (Actor/Actress)
Robert Ellis (Babe Ruth as a Boy)
Lloyd Gough (Baston)
Matt Briggs (Col. Ruppert)
Paul Cavanagh (Dr. Menzies)
Tony Taylor (The Kid)
Richard Lane (Coach)
Mark Koenig (Himself)
Harry Wismer (Sports Announcer)
Melvin Allen (Sports Announcers)
H.V. Kaltenborn (News Announcer)
Johnny Grant (Reporter)
Pat Flaherty (Bill Corrigan)
Knox Manning (Narrator)
Gertrude Niesen (Nightclub Singer)
Stanley Clements (Western Union Boy)