Dennis Quaid (Lt. Tuck Pendelton)
Martin Short (Jack Putter)
Meg Ryan (Lydia Maxwell)
Kevin McCarthy (Victor Scrimshaw)
Fiona Lewis (Dr. Margaret Canker)
Frank Miller (Scrimshaw's Henchman)
John Miranda (Man in Elevator)
Charles Aidman (Speaker at Banquet)
Laura Waterbury (Supermarket Customer)
Jeffrey Boam (Lydia's Interview)
Chuck Jones (Supermarket Customer)
Neil Ross (Pod Computer)
Herb Mitchell (Camera Store Clerk)
Jason Laskay (Scrimshaw's Henchman)
Dick Miller (Cab Driver)
Terry McGovern (Travel Agent)
Robert Gray (Lab Assault Henchman)
Joe Flaherty (Waiting Room Patient)
Grainger Hines (Rusty)
Alan Blumenfeld (Man with Camera)
Jenny Gago (Lab Technician)
Richard McGonagle (Cop)
Andrea Martin (Waiting Room Patient)
Christine Avila (Lab Technician)
Rance Howard (Supermarket Customer)
William Schallert (Dr. Greenbush)
John Hora (Ozzie Wexler)
Mark L. Taylor (Dr. Niles)
Orson Bean (Lydia's Editor)
Kevin Hooks (Duane)
Kathleen Freeman (Dream Lady)
Archie Hahn III (Messenger)
Kenneth Tobey (Man in Restroom)
Henry Gibson (Mr. Wormwood)
Vernon Wells (Mr. Igoe)
Robert Picardo (The Cowboy)
Wendy Schaal (Wendy)
Harold Sylvester (Peter Blanchard)