George Clooney (Ulysses Everett McGill)
John Turturro (Pete)
Tim Blake Nelson (Delmar)
Charles Durning (Pappy O'Daniel)
John Goodman (Big Dan Teague)
Musetta Vander (Siren)
Wayne Duvall (Homer Stokes)
Daniel Von Bargen (Sheriff Cooley)
J.R. Horne (Pappy's Staff)
Brian Reddy (Pappy's Staff)
Frank Collison (Wash Hogwallop)
Ray McKinnon (Vernon T. Waldrip)
Del Pentecost (Junior O'Daniel)
Michael Badalucco (George Nelson)
Holly Hunter (Penny)
Stephen Root (Radio Station Man)
Chris Thomas King (Tommy Johnson)