Don Ameche (Henry Van Cleve)
Gene Tierney (Martha)
Charles Coburn (Hugo Van Cleve)
Marjorie Main (Mrs. Strabel)
Laird Cregar (His Excellency)
Grayce Hampton (Albert's Mother)
Charles Halton (Clerk in Britano's)
Alfred Hall (Albert's Father)
James Flavin (Policeman)
Edwin Maxwell (Doctor)
Gerald Oliver Smith (Smith)
Michael McLean (Henry at Age 15 Months)
Scotty Beckett (Henry (youngest))
Doris Merrick (Nurse)
Helene Reynolds (Peggy Nash)
Aubrey Mather (James)
Michael Ames (Jack Van Cleve)
Leonard Carey (Flogdell)
Clarence Muse (Jasper)
Dickie Moore (Henry (younger))
Dick Jones (Albert (younger))
Trudy Marshall (Jane)
Florence Bates (Mrs. Craig)
Clara Blandick (Grandmother)
Anita Bolster (Mrs. Cooper-Cooper)
Nino Pipitone (Jack as a Child)
Claire Du Brey (Miss Ralston)
Spring Byington (Bertha Van Cleve)
Louis Calhern (Randolph Van Cleve)
Allyn Joslyn (Albert Van Cleve)
Eugene Pallette (E.F. Strabel)
Signe Hasso (Mademoiselle)