Robin Williams (Patch Adams)
Daniel London (Trumen)
Monica Potter (Carin)
Philip Seymour Hoffman (Mitch)
Bob Gunton (Dean Walcott)
Ryan Hurst (Neil)
Daniella Kuhn (Adelane)
Jake Bowen (Bryan)
Peter Coyote (Bill Davis)
James Greene (Bile)
Michael Jeter (Rudy)
Harold Gould (Arthur Mendelson)
Richard Kiley (Dr. Titan)
Josef Sommer (Dr. Eaton)
Irma P. Hall (Joletta)
Frances Lee McCain (Judy)
Harve Presnell (Dean Anderson)